Research
National systems, used in published research.
EDRWeb and TIER.Net do operational work first. The records they hold have also supported independent research into tuberculosis, HIV care, treatment outcomes, programme monitoring and data quality.
This is a selected reading list, not a claim of authorship. WAMTech built and has supported these systems; the studies and their conclusions belong to the named researchers and publishers.
- Selected papers
- 13
- Publication range
- 2014-2026
Selected literature
EDRWeb
Drug-resistant tuberculosis surveillance and treatment evidence
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Treatment outcomes 24 months after initiating short, all-oral bedaquiline-containing or injectable-containing rifampicin-resistant tuberculosis treatment regimens in South Africa: a retrospective cohort study
A national retrospective cohort comparison of short treatment regimens using patients registered in EDRWeb.
The Lancet Infectious Diseases View DOI -
Bedaquiline safety, efficacy, utilization and emergence of resistance following treatment of multidrug-resistant tuberculosis patients in South Africa: a retrospective cohort analysis
An analysis of treatment effectiveness, mortality, safety and resistance using EDRWeb data from 14 sites.
BMC Infectious Diseases View DOI -
Data quality assessment of a South African electronic registry for drug-resistant TB, 2015-2016
A direct assessment of EDRWeb completeness and concordance against patient source records.
Public Health Action View DOI -
Effect of bedaquiline on mortality in South African patients with drug-resistant tuberculosis: a retrospective cohort study
A national cohort study using EDRWeb and vital-statistics data to compare mortality between treatment regimens.
The Lancet Respiratory Medicine View DOI -
Persistently high early mortality despite rapid diagnostics for drug-resistant tuberculosis cases in South Africa
A survival analysis of EDRWeb records examining the timing and predictors of mortality.
International Journal of Tuberculosis and Lung Disease View DOI -
Predictors of mortality and treatment success during treatment for rifampicin-resistant tuberculosis within the South African National TB Programme, 2009 to 2011
A national case-register cohort analysis of mortality and treatment outcomes in EDRWeb.
International Journal of Infectious Diseases View DOI
Selected literature
TIER.Net
HIV and TB programme monitoring, outcomes and data quality
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Quality assessment of data for decentralised antiretroviral therapy referrals and laboratory results in the South African national electronic HIV management register TIER.Net
A comparison of TIER.Net records with national medicine-dispensing and laboratory information systems.
PLOS Global Public Health View DOI -
Record linkage without patient identifiers: proof of concept using data from South Africa's national HIV program
A privacy-preserving method that links TIER.Net clinical records with the National Health Laboratory Service cohort.
PLOS Global Public Health View DOI -
Assessment of facility-based tuberculosis data quality in an integrated HIV/TB database in three South African districts
An evaluation of completeness and agreement between TIER.Net's TB module and clinic records.
PLOS Global Public Health View DOI -
CD4 testing after initiation of antiretroviral therapy: analysis of routine data from the South African HIV programme
A four-district analysis of routine TIER.Net data covering more than one million people on treatment.
Southern African Journal of HIV Medicine View DOI -
Same-day antiretroviral therapy initiation for HIV-infected adults in South Africa: analysis of routine data
A study of same-day treatment initiation and retention using routine TIER.Net data from two districts.
PLOS One View DOI -
Misreporting of patient outcomes in the South African national HIV treatment database: consequences for programme planning, monitoring, and evaluation
A comparison of TIER.Net treatment outcomes with detailed record review and patient tracing.
Frontiers in Public Health View DOI -
A three-tier framework for monitoring antiretroviral therapy in high HIV burden settings
The foundational account of the monitoring model in which TIER.Net serves as the offline electronic register.
Journal of the International AIDS Society View DOI